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51.
肿瘤抑制蛋白p53的动力学在一定程度上可以决定DNA损伤后的细胞命运.p53的动力学行为与p53信号通路中p53-Mdm2振子模块密切相关.然而,p53的负调控子Mdm2的生成速率的增加使其在一些癌细胞中过表达.因此探讨Mdm2生成速率对p53动力学的影响有重要意义.同时,PDCD5作为p53的激活子也调控p53的表达.因此,本文针对PDCD5调控的p53-Mdm2振子模型,通过分岔分析获得了Mdm2生成速率所调控的p53的单稳态、振荡以及单稳态与振荡共存的动力学行为,且稳定性通过能量面进行了分析.此外,噪声强度对p53动力学的稳定性有重要的影响.因此,针对p53的振荡行为,探讨了噪声强度对势垒高度和周期的影响.本文所获得的结果对理解DNA损伤后的p53信号通路调控起到一定的指导作用. 相似文献
52.
Shuichi Ebisawa Takuro Tsutsumi Tetsuya Taketsugu 《Journal of computational chemistry》2021,42(1):27-39
A mathematical aspect of the anharmonic downward distortion following (ADDF) path is discussed. The ADDF method is utilized as an automated reaction path search method, which can explore transition state geometries on a potential energy surface from a potential minimum. We show that the maximum number of the ADD stationary paths intersecting the potential minimum is 2f + 1 ? 2 , where f denotes the degree of freedom of the system. We also show that the bifurcation of the ADD stationary path is essential to detect all the transition states connected from a given minimum. The ADDF computation is demonstrated for a H2O molecule in which pitchfork bifurcation is observed. 相似文献
53.
54.
In this paper, the dynamics of a system of two van der Pol equations with a finite delay are investigated. We show that there exist the stability switches and a sequence of Hopf bifurcations occur at the zero equilibrium when the delay varies. Using the theory of normal form and the center manifold theorem, the explicit expression for determining the direction of the Hopf bifurcations and the stability of the bifurcating periodic solutions are derived. 相似文献
55.
Bo Deng 《Journal of Differential Equations》2011,250(6):2940-2957
For a class of circuit models for neurons, it has been shown that the transmembrane electrical potentials in spike bursts have an inverse correlation with the intra-cellular energy conversion: the fewer spikes per burst the more energetic each spike is. Here we demonstrate that as the per-spike energy goes down to zero, a universal constant to the bifurcation of spike-bursts emerges in a similar way as Feigenbaum's constant does to the period-doubling bifurcation to chaos generation, and the new universal constant is the first natural number 1. 相似文献
56.
We propose an impulsive hybrid control method to control the
period-doubling bifurcations and stabilize unstable periodic orbits
embedded in a chaotic attractor of a small-world network. Simulation
results show that the bifurcations can be delayed or completely
eliminated. A periodic orbit of the system can be controlled to any
desired periodic orbit by using this method. 相似文献
57.
Based on the Routh-Hurwitz criterion, this paper investigates the stability of a new chaotic system. State feedback controllers are designed to control the chaotic system to the unsteady equilibrium points and limit cycle. Theoretical analyses give the range of value of control parameters to stabilize the unsteady equilibrium points of the chaotic system and its critical parameter for generating Hopf bifurcation. Certain nP periodic orbits can be stabilized by parameter adjustment. Numerical simulations indicate that the method can effectively guide the system trajectories to unsteady equilibrium points and periodic orbits. 相似文献
58.
In this paper, the dynamical behaviour of a linear impulsive system is discussed both theoretically and numerically. The existence and the stability of period-one solution are discussed by using a discrete map. The conditions of existence for flip bifurcation are derived by using the centre manifold theorem and bifurcation theorem. The bifurcation analysis shows that chaotic solutions appear via a cascade of period-doubling in some interval of parameters. Moreover, the periodic solutions, the bifurcation diagram, and the chaotic attractor, which show their consistence with the theoretical analyses, are given in an example. 相似文献
59.
Different types of bursting in Chay neuronal model 总被引:1,自引:0,他引:1
Based on actual neuronal firing activities, bursting in the Chay neuronal model is considered, in which V
K, reversal potentials for K+, V
C, reversal potentials for Ca2+, time kinetic constant λ
n
and an additional depolarized current I are considered as dynamical parameters. According to the number of the Hopf bifurcation points on the upper branch of the
bifurcation curve of fast subsystem, which is associated with the stable limit cycle corresponding to spiking states, different
types of bursting and their respective dynamical behavior are surveyed by means of fast-slow dynamical bifurcation analysis.
Supported by the National Natural Science Foundation of China (Grant Nos. 10432010, 10526002 and 10702002) 相似文献
60.
Alexander M. Krasnosel'skii Reinhard MennickenDmitrii I. Rachinskii 《Journal of Differential Equations》2002,179(1):97-132
The paper is concerned with Hopf bifurcations in systems of autonomous ordinary differential equations with a parameter. The principal distinction between usual theorems on Hopf bifurcations and our results is that here the linearized equation is degenerate and independent of the parameter. We present sufficient conditions for a parameter value to be a bifurcation point and analyze properties of small cycles arising in the vicinity of the equilibrium. Sublinear nonlinearities play the main role in the results obtained. 相似文献